The Nerd’s Page

If you’re a “science nerd” this page is for you! What follows is a collection of scientific studies that support ISOThrive’s health benefits. There are sections on Gut Health, Weight Management, Immunity Boost and Digestive Balance. Browse the literature and appreciate the full potential that is ISOThrive!


Gut Health Studies

The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, Dallas R., Nikhil Garge, Xinxin Zhang, Wei Sun, Thomas M. O’Connell, Maureen K. Bunger, and Scott J. Bultman. “The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon.” Cell Metabolism 13, no. 5 (2011): 517–26. doi:10.1016/j.cmet.2011.02.018.  Full Text »
Keeping bugs in check: The mucus layer as a critical component in maintaining intestinal homeostasis
Faderl, Martin, Mario Noti, Nadia Corazza, and Christoph Mueller. “Keeping Bugs in Check: The Mucus Layer as a Critical Component in Maintaining Intestinal Homeostasis.” IUBMB Life, 2015. doi:10.1002/iub.1374.  Full Text »
The composition of the gut microbiota shapes the colon mucus barrier
Jakobsson, Hedvig E, Ana M Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C Hansson, and Malin Ev Johansson. “The Composition of the Gut Microbiota Shapes the Colon Mucus Barrier.” EMBO Reports 16 (2015): 164–77. doi:10.15252/embr.  Full Text »
Mucus and the goblet cell
Johansson, Malin E V, and Gunnar C. Hansson. “Mucus and the Goblet Cell.” In Digestive Diseases, 31:305–9, 2013. doi:10.1159/000354683.  Full Text »
Prioritization of a plant polysaccharide over a mucus carbohydrate is enforced by a Bacteroides hybrid two-component system
Lynch, Jonathan B., and Justin L. Sonnenburg. “Prioritization of a Plant Polysaccharide over a Mucus Carbohydrate Is Enforced by a Bacteroides Hybrid Two-Component System.” Molecular Microbiology 85, no. 3 (2012): 478–91. doi:10.1111/j.1365-2958.2012.08123.x.  Full Text »
Think Globally, Act Locally: Regulated Deployment of Polysaccharide Degradation Abilities by our Symbiotic Gut Bacteria
Martens, Eric. “Think Globally, Act Locally: Regulated Deployment of Polysaccharide Degradation Abilities by our Symbiotic Gut Bacteria.” The FASEB Journal 29, no. 1 Supplement (2015): 91-2.  Abstract »
Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes
Musso, Giovanni, Roberto Gambino, and Maurizio Cassader. “Interactions between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes.” Annual Review of Medicine 62 (2011): 361–80. doi:10.1146/annurev-med-012510-175505.  Abstract »
Glycan foraging in vivo by an intestine-adapted bacterial symbiont
Sonnenburg, Justin L, Jian Xu, Douglas D Leip, Chien-Huan Chen, Benjamin P Westover, Jeremy Weatherford, Jeremy D Buhler, and Jeffrey I Gordon. “Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont.” Science (New York, N.Y.) 307, no. 5717 (2005): 1955–59. doi:10.1126/science.1109051.  Abstract »
Fiber’s Cancer-Fighting Effect Depends on Gut Bacteria
by Rachael Rettner  Full Text »
Fiber-Famished Gut Microbes Linked to Poor Health
by Katherine Harmon Courage  Full Text »

Weight Management: Human Studies

Effect of prebiotic supplementation and calcium intake on body mass index
Steven a Abrams et al., “Effect of Prebiotic Supplementation and Calcium Intake on Body Mass Index.,” The Journal of Pediatrics 151, no. 3 (2007): 293–98, doi:10.1016/j.jpeds.2007.03.043.  Abstract »
Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men
Bridie J Archer et al., “Effect of Fat Replacement by Inulin or Lupin-Kernel Fibre on Sausage Patty Acceptability, Post-Meal Perceptions of Satiety and Food Intake in Men.,” The British Journal of Nutrition 91, no. 4 (April 2004): 591–99, doi:10.1079/BJN20031088.  Full Text »
Oligofructose promotes satiety in healthy human: a pilot study
P D Cani et al., “Oligofructose Promotes Satiety in Healthy Human: A Pilot Study,” European Journal of Clinical Nutrition 60, no. 5 (December 7, 2005): 567–72, doi:10.1038/sj.ejcn.1602350.  Full Text »
Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal
Patrice D Cani et al., “Gut Microbiota Fermentation of Prebiotics Increases Satietogenic and Incretin Gut Peptide Production with Consequences for Appetite Sensation and Glucose Response after a Meal.,” The American Journal of Clinical Nutrition 90, no. 5 (November 2009): 1236–43, doi:10.3945/ajcn.2009.28095.  Full Text »
Yacon syrup: Beneficial effects on obesity and insulin resistance in humans
Susana Genta et al., “Yacon Syrup: Beneficial Effects on Obesity and Insulin Resistance in Humans,” Clinical Nutrition 28, no. 2 (2009): 182–87, doi:10.1016/j.clnu.2009.01.013.  Abstract »
Prebiotic Fiber Consumption Decreases Energy Intake in Overweight and Obese Children
Megan Hume et al., “Prebiotic Fiber Consumption Decreases Energy Intake in Overweight and Obese Children,” The FASEB Journal 29, no. 1 Supplement (April 1, 2015).  Abstract »
Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children
Alissa Nicolucci et al., “Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children,” The FASEB Journal 29, no. 1 Supplement (April 1, 2015).  Abstract »
Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults
Jill Parnell and Raylene Reimer, “Weight Loss during Oligofructose Supplementation Is Associated with Decreased Ghrelin and Increased Peptide YY in Overweight and Obese Adults,” American Journal of Clinical Nutrition 89, no. 6 (2009): 1751–59, doi:10.3945/ajcn.2009.27465.  Full Text »

Weight Management: Animal Studies

Combined effects of oligofructose and Bifidobacterium animalis on gut microbiota and glycemia in obese rats
Marc R Bomhof et al., “Combined Effects of Oligofructose and Bifidobacterium Animalis on Gut Microbiota and Glycemia in Obese Rats.,” Obesity (Silver Spring, Md.) 22, no. 3 (March 2014): 763–71, doi:10.1002/oby.20632.  Full Text »
Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1
Patrice D. Cani et al., “Oligofructose Promotes Satiety in Rats Fed a High-Fat Diet: Involvement of Glucagon-Like Peptide-1,” Obesity Research 13, no. 6 (June 6, 2005): 1000–1007, doi:10.1038/oby.2005.117.  Full Text »
Physiological effects of dietary fructans extracted from Agave tequilana Gto. and Dasylirion spp
Judith E. Urías-Silvas et al., “Physiological Effects of Dietary Fructans Extracted from Agave Tequilana Gto. and Dasylirion Spp.,” British Journal of Nutrition 99, no. 02 (August 22, 2007): 254–61, doi:10.1017/S0007114507795338.  Full Text »

Weight Management: Review Articles

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota
Patrice D Cani and Nathalie M Delzenne, “Interplay between Obesity and Associated Metabolic Disorders: New Insights into the Gut Microbiota.,” Current Opinion in Pharmacology 9, no. 6 (December 2009): 737–43, doi:10.1016/j.coph.2009.06.016.  Full Text »
Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1.  Abstract »
Gut microbiota and metabolic disorders: how prebiotic can work?
Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047.  Full Text »
Hypothesis: Bacteria Control Host Appetites
Vic Norris, Franck Molina, and Andrew T Gewirtz, “Hypothesis: Bacteria Control Host Appetites.,” Journal of Bacteriology 195, no. 3 (February 2013): 411–16, doi:10.1128/JB.01384-12.  Full Text »
Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome
Jill A Parnell and Raylene A Reimer, “Prebiotic Fiber Modulation of the Gut Microbiota Improves Risk Factors for Obesity and the Metabolic Syndrome.,” Gut Microbes 3, no. 1 (January ): 29–34, doi:10.4161/gmic.19246.  Full Text »
Prebiotic effects: metabolic and health benefits
Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363.  Full Text »
Gut microbiota and obesity
Emidio Scarpellini et al., “Gut Microbiota and Obesity,” Internal and Emergency Medicine 5, no. S1 (September 24, 2010): 53–56, doi:10.1007/s11739-010-0450-1.  Abstract »

Immunity Boost: Human Studies

Faecal SigA secretion in infants fed on pre- or probiotic infant formula
Bakker‐Zierikzee, A. M., Tol, V. E., Kroes, H., Alles, M. S., Kok, F. J., & Bindels, J. G. (2006). Faecal SIgA secretion in infants fed on pre‐or probiotic infant formula. Pediatric Allergy and Immunology, 17(2), 134-140.  Abstract »
Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial.
E Furrie et al., “Synbiotic Therapy (Bifidobacterium longum/Synergy 1) Initiates Resolution of Inflammation in Patients with Active Ulcerative Colitis: A Randomised Controlled Pilot Trial.,” Gut 54, no. 2 (February 2005): 242–49, doi:10.1136/gut.2004.044834.  Full Text »
Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial
Gori, A., Rizzardini, G., Van’t Land, B., Amor, K. B., Van Schaik, J., Torti, C., … & Clerici, M. (2011). Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the “COPA” pilot randomized trial. Mucosal immunology, 4(5), 554-563.  Full Text »
Effects of Oligosaccharide on the Faecal Flora and Non-Specific Immune System in Elderly People
Y Guigoz et al., “Effects of Oligosaccharide on the Faecal Flora and Non-Specific Immune System in Elderly People,” Nutrition Research 22, no. 1–2 (January 1, 2002): 13–25, doi:10.1016/S0271-5317(01)00354-2.  Abstract »
Clinical, microbiological, and immunological effects of fructo‐oligosaccharide in patients with Crohn’s disease
J O Lindsay et al., “Clinical, Microbiological, and Immunological Effects of Fructo-Oligosaccharide in Patients with Crohn’s Disease.,” Gut 55, no. 3 (March 2006): 348–55, doi:10.1136/gut.2005.074971.  Full Text »
A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age
G Moro et al., “A Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Atopic Dermatitis during the First Six Months of Age.,” Archives of Disease in Childhood 91, no. 10 (October 2006): 814–19, doi:10.1136/adc.2006.098251.  Full Text »
Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients.
Monika Roller et al., “Consumption of Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Has Minor Effects on Selected Immune Parameters in Polypectomised and Colon Cancer Patients.,” The British Journal of Nutrition 97, no. 4 (April 2007): 676–84, doi:10.1017/S0007114507450292.  Full Text »
Systemic inflammatory markers in older persons: the effect of oral nutritional supplementation with prebiotics
E J Schiffrin et al., “Systemic Inflammatory Markers in Older Persons: The Effect of Oral Nutritional Supplementation with Prebiotics.,” The Journal of Nutrition, Health & Aging 11, no. 6 (January ): 475–79.  Abstract »
Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides.
Petra A M J Scholtens et al., “Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides.,” The Journal of Nutrition 138, no. 6 (June 2008): 1141–47.  Full Text »
Characterization and in vitro immunomodulatory screening of fructo-oligosaccharides of Asparagus racemosus Willd.
Mayank Thakur et al., “Characterization and in Vitro Immunomodulatory Screening of Fructo-Oligosaccharides of Asparagus Racemosus Willd.,” International Journal of Biological Macromolecules 50, no. 1 (January 1, 2012): 77–81, doi:10.1016/j.ijbiomac.2011.09.027.  Abstract »
Short-term effect of prebiotics administration on stool characteristics and serum cytokines dynamics in very young children with acute diarrhea.
Nachum Vaisman et al., “Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea.,” Nutrients 2, no. 7 (July 30, 2010): 683–92, doi:10.3390/nu2070683.  Full Text »
A specific mixture of short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy
E van Hoffen et al., “A Specific Mixture of Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides Induces a Beneficial Immunoglobulin Profile in Infants at High Risk for Allergy.,” Allergy 64, no. 3 (March 2009): 484–87, doi:10.1111/j.1398-9995.2008.01765.x.  Full Text »
Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers
Jelena Vulevic et al., “Modulation of the Fecal Microflora Profile and Immune Function by a Novel Trans-Galactooligosaccharide Mixture (B-GOS) in Healthy Elderly Volunteers.,” The American Journal of Clinical Nutrition 88, no. 5 (November 1, 2008): 1438–46, doi:10.3945/ajcn.2008.26242.  Full Text »

Immunity Boost: Animal Studies

Supplementation with galacto-oligosaccharides increases the percentage of NK cells and reduces colitis severity in Smad3-deficient mice.
Anita Gopalakrishnan et al., “Supplementation with Galacto-Oligosaccharides Increases the Percentage of NK Cells and Reduces Colitis Severity in Smad3-Deficient Mice.,” The Journal of Nutrition 142, no. 7 (July 2012): 1336–42, doi:10.3945/jn.111.154732.  Full Text »
Dietary oligofructose and inulin modulate immune functions in mice.
K.A Kelly-Quagliana, P.D Nelson, and R.K Buddington, “Dietary Oligofructose and Inulin Modulate Immune Functions in Mice,” Nutrition Research 23, no. 2 (February 2003): 257–67, doi:10.1016/S0271-5317(02)00516-X.  Abstract »
Isomalto-oligosaccharides polarize Th1-like responses in intestinal and systemic immunity in mice.
Hiroyuki Mizubuchi et al., “Isomalto-Oligosaccharides Polarize Th1-like Responses in Intestinal and Systemic Immunity in Mice.,” The Journal of Nutrition 135, no. 12 (December 2005): 2857–61.  Full Text »
Prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactismodulates intestinal immune functions in rats
Monika Roller, Gerhard Rechkemmer, and Bernhard Watzl, “Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Modulates Intestinal Immune Functions in Rats.,” The Journal of Nutrition 134, no. 1 (January 2004): 153–56.  Full Text »
A potential role for CD25+ regulatory T-cells in the protection against casein allergy by dietary non-digestible carbohydrates
Bastiaan Schouten et al., “A Potential Role for CD25+ Regulatory T-Cells in the Protection against Casein Allergy by Dietary Non-Digestible Carbohydrates,” British Journal of Nutrition 107, no. 01 (June 23, 2011): 96–105, doi:10.1017/S0007114511002637.  Full Text »
Oligosaccharide-induced whey-specific CD25(+) regulatory T-cells are involved in the suppression of cow milk allergy in mice
Bastiaan Schouten et al., “Oligosaccharide-Induced Whey-Specific CD25(+) Regulatory T-Cells Are Involved in the Suppression of Cow Milk Allergy in Mice.,” The Journal of Nutrition 140, no. 4 (April 1, 2010): 835–41, doi:10.3945/jn.109.116061.  Full Text »
Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice
Arjan P Vos et al., “Dietary Supplementation of Neutral and Acidic Oligosaccharides Enhances Th1-Dependent Vaccination Responses in Mice.,” Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology 18, no. 4 (June 2007): 304–12, doi:10.1111/j.1399-3038.2007.00515.x.  Abstract »

Immunity Boost: Review Articles

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota
Patrice D Cani and Nathalie M Delzenne, “Interplay between Obesity and Associated Metabolic Disorders: New Insights into the Gut Microbiota.,” Current Opinion in Pharmacology 9, no. 6 (December 2009): 737–43, doi:10.1016/j.coph.2009.06.016.  Full Text »
Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1.  Abstract »
Gut microbiota and metabolic disorders: how prebiotic can work?
Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047.  Full Text »
The inflammatory status of old age can be nurtured from the intestinal environment.
Yves Guigoz, Joël Doré, and Eduardo J Schiffrin, “The Inflammatory Status of Old Age Can Be Nurtured from the Intestinal Environment.,” Current Opinion in Clinical Nutrition and Metabolic Care 11, no. 1 (January 2008): 13–20, doi:10.1097/MCO.0b013e3282f2bfdf.  Abstract »
Prebiotics
Thea Scantlebury Manning and Glenn R Gibson, “Microbial-Gut Interactions in Health and Disease. Prebiotics.,” Best Practice & Research. Clinical Gastroenterology 18, no. 2 (April 2004): 287–98, doi:10.1016/j.bpg.2003.10.008.  Abstract »
Hypothesis: Bacteria Control Host Appetites
Vic Norris, Franck Molina, and Andrew T Gewirtz, “Hypothesis: Bacteria Control Host Appetites.,” Journal of Bacteriology 195, no. 3 (February 2013): 411–16, doi:10.1128/JB.01384-12.  Full Text »
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
G R Gibson and M B Roberfroid, “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.,” The Journal of Nutrition 125, no. 6 (July 1995): 1401–12.  Full Text »
Dietary fiber, Inulin, and oligofructose: A review comparing their physiological effects
M Roberfroid, “Dietary Fiber, Inulin, and Oligofructose: A Review Comparing Their Physiological Effects.,” Critical Reviews in Food Science and Nutrition 33, no. 2 (January 1993): 103–48, doi:10.1080/10408399309527616.  Abstract »
Prebiotic effects: metabolic and health benefits
Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363.  Full Text »
Nondigestible oligo-and polysaccharides (Dietary Fiber): their physiology and role in human health and food
B.C. Tungland and D. Meyer, “Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food,” Comprehensive Reviews in Food Science and Food Safety 1, no. 3 (October 2002): 90–109, doi:10.1111/j.1541-4337.2002.tb00009.x.  Full Text »

Digestive Balance: Human Studies

Effect of consumption of a ready-to-eat breakfast cereal containing inulin on the intestinal milieu and blood lipids in healthy male volunteers
F Brighenti et al., “Effect of Consumption of a Ready-to-Eat Breakfast Cereal Containing Inulin on the Intestinal Milieu and Blood Lipids in Healthy Male Volunteers.,” European Journal of Clinical Nutrition 53, no. 9 (September 1999): 726–33.  Full Text »
Effects of isomalto-oligosaccharides on bowel functions and indicators of nutritional status in constipated elderly men
H L Chen et al., “Effects of Isomalto-Oligosaccharides on Bowel Functions and Indicators of Nutritional Status in Constipated Elderly Men.,” Journal of the American College of Nutrition 20, no. 1 (February 2001): 44–49.  Abstract »
Yacon syrup: Beneficial effects on obesity and insulin resistance in humans
Susana Genta et al., “Yacon Syrup: Beneficial Effects on Obesity and Insulin Resistance in Humans,” Clinical Nutrition 28, no. 2 (2009): 182–87, doi:10.1016/j.clnu.2009.01.013.”   Abstract »
Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children
Alissa Nicolucci, Megan Hume, and Raylene Reimer, “Effect of Prebiotic Fiber-Induced Changes in Gut Microbiota on Adiposity in Obese and Overweight Children,” The FASEB Journal 29, no. 1 Supplement (April 1, 2015).  Abstract »
Use of isomalto-oligosaccharide in the treatment of lipid profiles and constipation in hemodialysis patients
Hsueh-Fang Wang et al., “Use of Isomalto-Oligosaccharide in the Treatment of Lipid Profiles and Constipation in Hemodialysis Patients,” Journal of Renal Nutrition 11, no. 2 (April 4, 2001): 73–79, doi:10.1016/S1051-2276(01)92591-9.  Abstract »
Long-term supplementation of isomalto-oligosaccharides improved colonic microflora profile, bowel function, and blood cholesterol levels in constipated elderly people—A placebo-controlled, diet-controlled trial
Chi-Hua Yen et al., “Long-Term Supplementation of Isomalto-Oligosaccharides Improved Colonic Microflora Profile, Bowel Function, and Blood Cholesterol Levels in Constipated Elderly people—A Placebo-Controlled, Diet-Controlled Trial,” Nutrition 27, no. 4 (April 4, 2011): 445–50, doi:10.1016/j.nut.2010.05.012.  Abstract »

Digestive Balance: Review Articles

Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1.  Abstract »
Gut microbiota and metabolic disorders: how prebiotic can work?
Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047.  Full Text »
Microbial-gut interactions in health and disease. Prebiotics.
Thea Scantlebury Manning and Glenn R Gibson, “Microbial-Gut Interactions in Health and Disease. Prebiotics.,” Best Practice & Research. Clinical Gastroenterology 18, no. 2 (April 2004): 287–98, doi:10.1016/j.bpg.2003.10.008.  Abstract »
Hypothesis: Bacteria Control Host Appetites
Vic Norris, Franck Molina, and Andrew T Gewirtz, “Hypothesis: Bacteria Control Host Appetites.,” Journal of Bacteriology 195, no. 3 (February 2013): 411–16, doi:10.1128/JB.01384-12.  Full Text »
Dietary modulation of the human colonic microbiota: Introducing the Concept of Prebiotics
G R Gibson and M B Roberfroid, “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.,” The Journal of Nutrition 125, no. 6 (July 1995): 1401–12.  Full Text »
Dietary fiber, Inulin, and oligofructose: A review comparing their physiological effects
M Roberfroid, “Dietary Fiber, Inulin, and Oligofructose: A Review Comparing Their Physiological Effects.,” Critical Reviews in Food Science and Nutrition 33, no. 2 (January 1993): 103–48, doi:10.1080/10408399309527616.  Abstract »
Prebiotic effects: metabolic and health benefits
Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363.  Full Text »
Nondigestible oligo-and polysaccharides (Dietary Fiber): their physiology and role in human health and food
B.C. Tungland and D. Meyer, “Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food,” Comprehensive Reviews in Food Science and Food Safety 1, no. 3 (October 2002): 90–109, doi:10.1111/j.1541-4337.2002.tb00009.x.  Full Text »

Heart Health: Human Studies

Effect of Short-Term Ingestion of Konjac Glucomannan on Serum Cholesterol in Healthy Men
A Arvill and L Bodin, “Effect of Short-Term Ingestion of Konjac Glucomannan on Serum Cholesterol in Healthy Men.,” The American Journal of Clinical Nutrition 61, no. 3 (March 1995): 585–89, http://www.ncbi.nlm.nih.gov/pubmed/7872224.  Abstract »
Effect of Oral Inulin Administration on Lipid Profile and Insulin Sensitivity in Subjects with Obesity and Dyslipidemia
Blanca R Balcázar-Muñoz, Esperanza Martínez-Abundis, and Manuel González-Ortiz, “[Effect of Oral Inulin Administration on Lipid Profile and Insulin Sensitivity in Subjects with Obesity and Dyslipidemia].,” Revista Médica de Chile 131, no. 6 (June 2003): 597–604, http://www.ncbi.nlm.nih.gov/pubmed/12942586.  Abstract »
Effect of Consumption of a Ready-to-Eat Breakfast Cereal Containing Inulin on the Intestinal Milieu and Blood Lipids in Healthy Male Volunteers
F Brighenti et al., “Effect of Consumption of a Ready-to-Eat Breakfast Cereal Containing Inulin on the Intestinal Milieu and Blood Lipids in Healthy Male Volunteers.,” European Journal of Clinical Nutrition 53, no. 9 (September 1999): 726–33, http://www.ncbi.nlm.nih.gov/pubmed/10509770.  Abstract »
Effects of Dietary Inulin on Serum Lipids, Blood Glucose and the Gastrointestinal Environment in Hypercholesterolemic Men
Jennifer L. Causey et al., “Effects of Dietary Inulin on Serum Lipids, Blood Glucose and the Gastrointestinal Environment in Hypercholesterolemic Men,” Nutrition Research 20, no. 2 (February 2000): 191–201, doi:10.1016/S0271-5317(99)00152-9.   Abstract »
Konjac Supplement Alleviated Hypercholesterolemia and Hyperglycemia in Type 2 Diabetic Subjects–a Randomized Double-Blind Trial
Hsiao-Ling Chen et al., “Konjac Supplement Alleviated Hypercholesterolemia and Hyperglycemia in Type 2 Diabetic Subjects–a Randomized Double-Blind Trial.,” Journal of the American College of Nutrition 22, no. 1 (March 2003): 36–42, http://www.ncbi.nlm.nih.gov/pubmed/12569112.  Abstract »
Effects of Dietary Inulin on Serum Lipids
M H Davidson and K C Maki, “Effects of Dietary Inulin on Serum Lipids.,” The Journal of Nutrition 129, no. 7 Suppl (July 1999): 1474S – 7S, http://www.ncbi.nlm.nih.gov/pubmed/10395624.  Full Text »
Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health
Hidemasa HIDAKA, Yasuhito TASHIRO, and Toshiaki EIDA, “Proliferation of Bifidobacteria by Oligosaccharides and Their Useful Effect on Human Health,” Bifidobacteria and Microflora 10, no. 1 (January 1, 1991): 65–79, doi:10.12938/bifidus1982.10.1_65.  Abstract »
The Effect of the Daily Intake of Inulin on Fasting Lipid, Insulin and Glucose Concentrations in Middle-Aged Men and Women
K G Jackson et al., “The Effect of the Daily Intake of Inulin on Fasting Lipid, Insulin and Glucose Concentrations in Middle-Aged Men and Women.,” The British Journal of Nutrition 82, no. 1 (July 1999): 23–30, http://www.ncbi.nlm.nih.gov/pubmed/10655953.  Abstract »
Addition of Inulin to a Moderately High-Carbohydrate Diet Reduces Hepatic Lipogenesis and Plasma Triacylglycerol Concentrations in Humans
Dominique Letexier, Frédérique Diraison, and Michel Beylot, “Addition of Inulin to a Moderately High-Carbohydrate Diet Reduces Hepatic Lipogenesis and Plasma Triacylglycerol Concentrations in Humans.,” The American Journal of Clinical Nutrition 77, no. 3 (March 2003): 559–64, http://www.ncbi.nlm.nih.gov/pubmed/12600843.  Full Text »
Childhood Obesity Treatment: Double Blinded Trial on Dietary Fibres (glucomannan) versus Placebo
L Vido et al., “Childhood Obesity Treatment: Double Blinded Trial on Dietary Fibres (glucomannan) versus Placebo.,” Pädiatrie Und Pädologie 28, no. 5 (January 1993): 133–36, http://www.ncbi.nlm.nih.gov/pubmed/8247594.  Abstract »
L-Rhamnose and Lactulose Decrease Serum Triacylglycerols and Their Rates of Synthesis, but Do Not Affect Serum Cholesterol Concentrations in Men
Janet A Vogt et al., “L-Rhamnose and Lactulose Decrease Serum Triacylglycerols and Their Rates of Synthesis, but Do Not Affect Serum Cholesterol Concentrations in Men.,” The Journal of Nutrition 136, no. 8 (August 2006): 2160–66, http://www.ncbi.nlm.nih.gov/pubmed/16857835.  Full Text »
Beneficial Effects of Viscous Dietary Fiber from Konjac-Mannan in Subjects with the Insulin Resistance Syndrome: Results of a Controlled Metabolic Trial
V Vuksan et al., “Beneficial Effects of Viscous Dietary Fiber from Konjac-Mannan in Subjects with the Insulin Resistance Syndrome: Results of a Controlled Metabolic Trial.,” Diabetes Care 23, no. 1 (January 2000): 9–14, http://www.ncbi.nlm.nih.gov/pubmed/10857960.  Full Text »
Effect of Glucomannan on Obese Patients: A Clinical Study
D E Walsh, V Yaghoubian, and A Behforooz, “Effect of Glucomannan on Obese Patients: A Clinical Study.,” International Journal of Obesity 8, no. 4 (January 1984): 289–93, http://www.ncbi.nlm.nih.gov/pubmed/6096282.  Abstract »
Effects of a Carbohydrate-Restricted Diet with and without Supplemental Soluble Fiber on Plasma Low-Density Lipoprotein Cholesterol and Other Clinical Markers of Cardiovascular Risk
Richard J Wood et al., “Effects of a Carbohydrate-Restricted Diet with and without Supplemental Soluble Fiber on Plasma Low-Density Lipoprotein Cholesterol and Other Clinical Markers of Cardiovascular Risk.,” Metabolism: Clinical and Experimental 56, no. 1 (January 2007): 58–67, doi:10.1016/j.metabol.2006.08.021.  Abstract »
Effects of Fructo-Oligosaccharides on Blood Glucose and Serum Lipids in Diabetic Subjects
Kamejiro Yamashita, Koichi Kawai, and Mitsuo Itakura, “Effects of Fructo-Oligosaccharides on Blood Glucose and Serum Lipids in Diabetic Subjects,” Nutrition Research 4, no. 6 (November 11, 1984): 961–66, doi:10.1016/S0271-5317(84)80075-5.  Abstract »
Effect of Plant Sterols and Glucomannan on Lipids in Individuals with and without Type II Diabetes
M Yoshida et al., “Effect of Plant Sterols and Glucomannan on Lipids in Individuals with and without Type II Diabetes.,” European Journal of Clinical Nutrition 60, no. 4 (April 2006): 529–37, doi:10.1038/sj.ejcn.1602347.  Full Text »

Heart Health: Animal Studies

Xylooligosaccharides and Fructooligosaccharides Affect the Intestinal Microbiota and Precancerous Colonic Lesion Development in Rats
Cheng-Kuang Hsu et al., “Xylooligosaccharides and Fructooligosaccharides Affect the Intestinal Microbiota and Precancerous Colonic Lesion Development in Rats.,” The Journal of Nutrition 134, no. 6 (June 2004): 1523–28, http://www.ncbi.nlm.nih.gov/pubmed/15173423.  Full Text »
Effects of Fructans-Type Prebiotics on Lipid Metabolism
N M Delzenne and N Kok, “Effects of Fructans-Type Prebiotics on Lipid Metabolism.,” The American Journal of Clinical Nutrition 73, no. 2 Suppl (February 2001): 456S – 458S, http://www.ncbi.nlm.nih.gov/pubmed/11157357.  Full Text »
Low Density Lipoprotein Receptor mRNA in Rat Liver Is Affected by Resistant Starch of Beans
M Fukushima et al., “Low Density Lipoprotein Receptor mRNA in Rat Liver Is Affected by Resistant Starch of Beans.,” Lipids 36, no. 2 (February 2001): 129–34, http://www.ncbi.nlm.nih.gov/pubmed/11269692.  Abstract »
Effects of Chito-Oligosaccharide Supplementation on Performance, Nutrient Digestibility, and Serum Composition in Broiler Chickens
X J Li et al., “Effects of Chito-Oligosaccharide Supplementation on Performance, Nutrient Digestibility, and Serum Composition in Broiler Chickens.,” Poultry Science 86, no. 6 (June 2007): 1107–14, http://www.ncbi.nlm.nih.gov/pubmed/17495080.  Full Text »
Class 2 Resistant Starches Lower Plasma and Liver Lipids and Improve Mineral Retention in Rats
H W Lopez et al., “Class 2 Resistant Starches Lower Plasma and Liver Lipids and Improve Mineral Retention in Rats.,” The Journal of Nutrition 131, no. 4 (April 2001): 1283–89, http://www.ncbi.nlm.nih.gov/pubmed/11285339.  Full Text »
Effects of Soluble Corn Bran Arabinoxylans on Cecal Digestion, Lipid Metabolism, and Mineral Balance (Ca, Mg) in Rats
H W Lopez et al., “Effects of Soluble Corn Bran Arabinoxylans on Cecal Digestion, Lipid Metabolism, and Mineral Balance (Ca, Mg) in Rats.,” The Journal of Nutritional Biochemistry 10, no. 9 (September 1999): 500–509, http://www.ncbi.nlm.nih.gov/pubmed/15539329.  Abstract »
Dietary Inulin Lowers Plasma Cholesterol and Triacylglycerol and Alters Biliary Bile Acid Profile in Hamsters
E A Trautwein, D Rieckhoff, and H F Erbersdobler, “Dietary Inulin Lowers Plasma Cholesterol and Triacylglycerol and Alters Biliary Bile Acid Profile in Hamsters.,” The Journal of Nutrition 128, no. 11 (November 1998): 1937–43, http://www.ncbi.nlm.nih.gov/pubmed/9808646.  Full Text »

Heart Health: Review Articles

Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?
Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease?,” Genes & Nutrition 6, no. 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1.  Abstract »
Prebiotics and Lipid Metabolism
Nathalie M Delzenne and Christine M Williams, “Prebiotics and Lipid Metabolism.,” Current Opinion in Lipidology 13, no. 1 (February 2002): 61–67, http://www.ncbi.nlm.nih.gov/pubmed/11790964.  Abstract »
Oligosaccharides: State of the Art
N M Delzenne, “Oligosaccharides: State of the Art.,” The Proceedings of the Nutrition Society 62, no. 1 (February 2003): 177–82, http://www.ncbi.nlm.nih.gov/pubmed/12749343.  Full Text »
Gut microbiota and metabolic disorders: how prebiotic can work?
Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work?,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047.  Full Text »
Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings
Lay-Gaik Ooi and Min-Tze Liong, “Cholesterol-Lowering Effects of Probiotics and Prebiotics: A Review of in Vivo and in Vitro Findings.,” International Journal of Molecular Sciences 11, no. 6 (January 2010): 2499–2522, doi:10.3390/ijms11062499.  Full Text »
Dietary modulation of the human colonic microbiota: updating the concept of prebiotics
G R Gibson and M B Roberfroid, “Dietary Modulation of the Human Colonic Microbiota: Introducing the Concept of Prebiotics.,” The Journal of Nutrition 125, no. 6 (July 1995): 1401–12, http://www.ncbi.nlm.nih.gov/pubmed/7782892.  Full Text »
Dietary fiber, Inulin, and oligofructose: A review comparing their physiological effects
M Roberfroid, “Dietary Fiber, Inulin, and Oligofructose: A Review Comparing Their Physiological Effects.,” Critical Reviews in Food Science and Nutrition 33, no. 2 (January 1993): 103–48, doi:10.1080/10408399309527616.  Abstract »
Prebiotic effects: metabolic and health benefits
Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363.  Full Text »
Nondigestible oligo-and polysaccharides (Dietary Fiber): their physiology and role in human health and food
B.C. Tungland and D. Meyer, “Nondigestible Oligo- and Polysaccharides (Dietary Fiber): Their Physiology and Role in Human Health and Food,” Comprehensive Reviews in Food Science and Food Safety 1, no. 3 (October 2002): 90–109, doi:10.1111/j.1541-4337.2002.tb00009.x.  Full Text »
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